Dr Enk and colleagues demonstrated with an early prototype of Tritube that small-bore ventilation with Ventrain is optimized in a cuffed airway. A pressure measurement line in the prototype Tritube enabled a reliable airway pressure monitoring using a cuff manometer. During the 30 minutes of ventilation with Ventrain (PaO2 61 [52-69] kpa; PaCO2 4.9 [4.2-6.2] kPa) hemodynamics were stable. This elegant study was executed in healthy pigs.