Spraider et al. Improved gas exchange and lung aeration in flow-controlled ventilation (FCV) compared to pressure-controlled ventilation (PCV) – A prospective, randomized porcine study. Abstract presented at ESICM 2019
In a randomized controlled porcine study, Spraider and colleagues demonstrated that FCV significantly improved gas exchange and maintained better lung aeration during 10 hours of ventilation, as compared to pressure controlled ventilation (PCV). Ventilation settings for FCV were individually optimized through compliance-guided pressure settings, while PCV settings were chosen according to the standard of care for lung-protective ventilation. Results showed a significantly better oxygenation in the FCV group (+24%, P=0.0097) while requiring a 53% lower minute volume (P <0.0001) to achieve normocapnia. Furthermore, pigs ventilated with FCV had an 8% higher fraction of normally aerated lung tissue (P=0.0068), as demonstrated by CT scans performed at the end of the experiment.
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The first randomized controlled trial on FCV® has now been published, demonstrating that during laryngeal surgery Tritube improves visibility of the surgical site as compared with a MLT 6.0. Moreover, the group of Prof Schumann showed that FCV® improves lung...