COVID-19 patients admitted to the ICU often require prolonged mechanical ventilation. The European Laryngological Society has issued an important statement, alerting clinicians for an unprecedented increase of laryngo-tracheal stenosis (LTS)¹.

COVID-19 has made safe performance of airway procedures a challenge, for diagnosis as well as treatment. It requires preparedness for prevention and timely management of LTS, with special attention to infection control.

The current strategies to manage the compromized airway include jet ventilation, high flow nasal oxygenation, tracheotomy and ECMO. While the first two options are minimally invasive, aerosols are generated and spread, also ventilation may be less effective in specific patients (e.g. obese). The opposite counts for the latter two options: tracheotomy and ECMO are highly invasive techniques with less aerosol generation and adequate ventilation.

Tritube® is an ultrathin endotracheal tube (OD 4.4mm) with a cuff. It provides a minimally invasive intubation in the compromized airway^2,3, provides a great surgical exposure^2–6, reduces aerosol generation and spread, and enables highly effective ventilation using Evone®^,6. As such Tritube and Evone were found key tools in managing the infraglottic difficult airway in the setting of the Coronavirus pandemic.⁸

Case report: Post-COVID-19 patient tracheal stenosis

A Post-COVID-19 patient presented with severe tracheal stenosis. While the ECMO team was standby Dr Nabil Shallik managed to successfully intubate and ventilate this patient with Tritube and Evone. Tritube provided the surgeons the workspace they needed, with minimized aerosol generation.

 The video demonstrates:

1. Field of interest examination on the airway and guidewire placement under spontaneous ventilation
2. Advancing Tritube over the guidewire
3. First time balloon dilatation
4. Removal of fibrous tissue
5. Second time balloon dilatation
6. Near normal tracheal shape and size

Ample clinical data clearly demonstrated clear benefits of using Tritube and Evone, managing the difficult airway or during laryngeal surgery. The following benefits were found:

• Minimized contamination risk for healthcare professionals, due to a sealed airway⁸
• An unprecedented view of the intubated airway, due to the thin lumen ^2,5,6
• A large surgical exposure and hygienic and clear sight with non-moving vocal cords ^2,4–6
• Easy intubation even in difficult airways due to the small outer diameter and malleable stylet ^2,3,9
• Awake intubation in patients with a difficult airway ^2,9
• Well tolerated when left in situ postoperatively, allowing patients to breathe and talk ^2,3,9
• More efficient ventilation, better oxygenation and CO2 removal^7,10,11

1. Piazza, C. et al. Long-term intubation and high rate of tracheostomy in COVID-19 patients might determine an unprecedented increase of airway stenoses: a call to action from the European Laryngological Society. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery (2020) doi:10.1007/s00405-020-06112-6.
2. Kristensen, M. S., de Wolf, M. W. P. & Rasmussen, L. S. Ventilation via the 2.4 mm internal diameter Tritube® with cuff – new possibilities in airway management. Acta Anaesthesiol Scand 61, 580–589 (2017).
3. Kristensen, M. S. & Abildstrøm, H. H. Endotracheal video-laryngoscope guided intubation with a 2.4 mm cuff’ed tube and active expiration by a dedicated ventilator versus a standard tube/ventilator. A randomized single blinded study in patients with a predicted difficult airway. – A paradigm shift in airway management? Abstract published at Euroanaesthesia 2019 3755, (2019).
4. Schmidt, J. et al. Flow-controlled ventilation during ear, nose and throat surgery: A prospective observational study. Eur J Anaesthesiol 36, 327–334 (2019).
5. Schmidt, J. et al. Glottic visibility for laryngeal surgery: Tritube vs. microlaryngeal tube: A randomised controlled trial. Eur J Anaesthesiol 36, 963–971 (2019).
6. Meulemans, J. et al. Evone® Flow-Controlled Ventilation During Upper Airway Surgery: A Clinical Feasibility Study and Safety Assessment. Front. Surg. 7, (2020).
7. Schmidt, J. et al. Improved lung recruitment and oxygenation during mandatory ventilation with a new expiratory ventilation assistance device: A controlled interventional trial in healthy pigs. Eur J Anaesthesiol 35, 736–744 (2018).
8. Nouraei, S. A. R., Girgis, M., Shorthouse, J., El-Boghdadly, K. & Ahmad, I. A multidisciplinary approach for managing the infraglottic difficult airway in the setting of the Coronavirus pandemic. Operative Techniques in Otolaryngology-Head and Neck Surgery 31, 128–137 (2020).
9. Jeyarajah, K. & Ahmad, I. Awake tracheal placement of the Tritube® under flexible bronchoscopic guidance | Case Studies. Anaesthesia Cases 2018–0097, (2018).
10. Weber, J., Schmidt, J., Straka, L., Wirth, S. & Schumann, S. Flow-controlled ventilation improves gas exchange in lung-healthy patients— a randomized interventional cross-over study. Acta Anaesthesiologica Scandinavica 64, 481–488 (2020).
11. Schmidt, J. et al. Flow-Controlled Ventilation Attenuates Lung Injury in a Porcine Model of Acute Respiratory Distress Syndrome: A Preclinical Randomized Controlled Study. Critical Care Medicine 48, e241–e248 (2020).